{"id":19800,"date":"2024-06-06T19:50:49","date_gmt":"2024-06-06T19:50:49","guid":{"rendered":"https:\/\/lifestylemedicine.org\/?p=19800"},"modified":"2025-07-10T21:52:25","modified_gmt":"2025-07-10T21:52:25","slug":"ornish-research","status":"publish","type":"post","link":"https:\/\/lifestylemedicine.org\/ornish-research\/","title":{"rendered":"Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients"},"content":{"rendered":"\n

Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients<\/h1>\n\n\n\n

By Alex Branch<\/strong>
ACLM Director of Communications<\/strong><\/p>\n\n\n\n

June 6, 2024<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

A randomized, controlled clinical trial study directed by lifestyle medicine pioneer Dean Ornish, MD, FACLM, founder of the Preventive Medicine Research Institute, demonstrated for the first time that an intensive lifestyle intervention, without drugs, significantly improved cognition and function in many patients with early dementia and Alzheimer\u2019s disease.<\/p>\n\n\n\n

The groundbreaking findings were published Friday, June 7 in Alzheimer\u2019s Research and Therapy<\/a>, <\/em>the leading peer-reviewed Alzheimer\u2019s translational research journal.<\/p>\n\n\n\n

\u201cI\u2019m cautiously optimistic and very encouraged by these findings, which may give many people new hope and new choices,\u201d Dr. Ornish said.  \u201cWe do not yet have a cure for Alzheimer\u2019s, but as the scientific community continues to pursue all avenues to identify potential treatments, we are now able to offer an improved quality of life to many people suffering from this terrible disease.\u201d<\/p>\n\n\n\n

About the study<\/h2>\n\n\n\n

For the trial, the research team randomly assigned 51 men and women with a diagnosis of mild cognitive impairment or early dementia due to Alzheimer\u2019s disease to two groups: an intensive lifestyle intervention group with no drugs added or a usual-care control comparison group who were told not to make any lifestyle changes.<\/p>\n\n\n\n

The intensive lifestyle program consisted of a whole-food, minimally processed plant-based diet, moderate aerobic exercise and strength training, stress management including meditation, stretching, breathing and imagery, and support groups for patients and their spouses or study partners. Meals were provided to participants and their spouses.<\/p>\n\n\n\n

Findings<\/h2>\n\n\n\n

After 20 weeks, results showed overall statistically significant differences between the intervention group and the randomized control group in cognition and function in three of the four standard tests used in FDA trials, as well as differences of borderline significance in the fourth test. Excluding a mathematical outlier, all four measures showed significant differences in cognition and function in the experimental group.<\/p>\n\n\n\n

Of the patients who experienced improvement, many reported regaining lost cognition and function. Specific examples included several patients who previously struggled to read books because they would forget what they just read now being able to finish the book and retain most of the information. Others reported regaining the ability to manage finances.<\/p>\n\n\n\n

\u201cAdding to the biological plausibility of the findings was a dose and response correlation between the degree of change in lifestyle and the degree of change in improvement in all four measures of cognitive function,\u201d Dr. Ornish said.<\/p>\n\n\n\n

Findings showed 71% of patients in the intervention group improved or were unchanged. None of the patients in the control group improved and 68% worsened.<\/p>\n\n\n\n

Regaining sense of self<\/h2>\n\n\n\n

Dr. Ornish noted that memory loss is such a disruptive occurrence that for some people a diagnosis of Alzheimer\u2019s disease of dementia becomes self-fulfilling. Their world shrinks. They don\u2019t go out for fear of embarrassment or getting lost and they enter a downward spiral.<\/p>\n\n\n\n

But one trial participant, a former business executive, reported in the study that he regained the ability to manage his own finances and investment. He was back to reconciling his family\u2019s monthly expenses and, as a result, he said \u201ca lot of self-worth comes back.\u201d<\/p>\n\n\n\n

One woman said she had returned to preparing financial reports for her family business, which she had been unable to do for five years. \u201cA deep sense of identity is returning,\u201d she said. \u201cIt\u2019s given me a new lease on life, and yet it\u2019s a familiarity and something I\u2019ve always prided myself on.  I\u2019m coming back like I was prior to the disease being diagnosed.  I feel like I\u2019m me<\/em> again\u2014an older but better version of me.\u201d<\/p>\n\n\n\n

Reframing prevention<\/h2>\n\n\n\n

New artificial intelligence-enabled technology tools are making it possible to predict that someone is likely to get Alzheimer\u2019s disease 10 years before it becomes clinically apparent, Dr. Ornish said. But many people are reluctant to find out because they believe there is nothing they can do about the result.<\/p>\n\n\n\n

\u201cNow we have shown you may be able to in many cases reverse the progression of early stage Alzheimer\u2019s disease,\u201d Dr. Ornish said. \u201cThe implication for prevention is that the earlier you intervene, the more likely it is to be positive in terms of protection, so the less you need to change in your lifestyle. I think clinicians can reframe their approach and encourage patients to find out if they have a family history.\u201d<\/p>\n\n\n\n

For everyone<\/h2>\n\n\n\n

The study noted that Alzheimer\u2019s disease is the fifth-leading cause of death among Americans aged 65 and older. In addition to its physical and emotional devastation, it is an expensive problem with an annual cost of more than $345 billion. By 2050, costs are projected to skyrocket to $1.1 trillion annually.<\/p>\n\n\n\n

\u201cA big obstacle that I struggle with \u2013 and that I am sure is familiar to ACLM \u2013 is people who hear \u2018diet and lifestyle\u2019 and think that is kind of boring; how powerful could that be,\u201d Dr. Ornish said. \u201cThey think it has to be high tech and expensive to be powerful. Our unique contribution is to use these state-of-the art, high-tech scientific measures to prove how powerful these simple lifestyle changes can often be.<\/p>\n\n\n\n

\u201c<\/strong>I designed this intervention so you don\u2019t have to have a lot of money to do it,\u201d Dr. Ornish said. \u201cThis is for everyone.\u201d<\/p>\n\n\n\n

For more information visit www.pmri.org<\/a>\u00a0and\u00a0www.ornish.com<\/a><\/p>\n\n\n\n

Listen to our full interview with Dr. Ornish<\/h2>\n\n\n\n
\n\nhttps:\/\/lifestylemedicine.org\/wp-content\/uploads\/2024\/06\/Ornish-Interview.mp3<\/a><\/audio>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"

Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients By Alex BranchACLM Director of Communications June 6, 2024 A randomized, controlled clinical trial study directed by lifestyle medicine pioneer Dean Ornish, MD, FACLM, founder of the Preventive Medicine Research Institute, demonstrated for the first time that an intensive lifestyle intervention, without drugs, significantly […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[67,13],"tags":[],"class_list":["post-19800","post","type-post","status-publish","format-standard","hentry","category-lifestyle-medicine-overview","category-research_innovation"],"acf":[],"yoast_head":"\nOrnish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients - American College of Lifestyle Medicine<\/title>\n<meta name=\"description\" content=\"A clinical trial study directed by Dr. Dean Ornish found that intensive lifestyle interventions can improve congnition and function in early dementia patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lifestylemedicine.org\/ornish-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients\" \/>\n<meta property=\"og:description\" content=\"A clinical trial study directed by Dr. Dean Ornish found that intensive lifestyle interventions can improve congnition and function in early dementia patients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lifestylemedicine.org\/ornish-research\/\" \/>\n<meta property=\"og:site_name\" content=\"American College of Lifestyle Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/lifestylemed\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-06T19:50:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-10T21:52:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lifestylemedicine.org\/wp-content\/uploads\/2025\/06\/brain-health-1024x579.webp\" \/>\n<meta name=\"author\" content=\"lesliecasey\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/lifestylemedicine.org\/ornish-research\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/lifestylemedicine.org\/ornish-research\/\"},\"author\":{\"name\":\"lesliecasey\",\"@id\":\"https:\/\/lifestylemedicine.org\/#\/schema\/person\/173dd2e9bc39f96bf4f8ef5292371e15\"},\"headline\":\"Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients\",\"datePublished\":\"2024-06-06T19:50:49+00:00\",\"dateModified\":\"2025-07-10T21:52:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/lifestylemedicine.org\/ornish-research\/\"},\"wordCount\":930,\"publisher\":{\"@id\":\"https:\/\/lifestylemedicine.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/lifestylemedicine.org\/ornish-research\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lifestylemedicine.org\/wp-content\/uploads\/2025\/06\/brain-health-1024x579.webp\",\"articleSection\":[\"Lifestyle Medicine Overview\",\"Research & Innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lifestylemedicine.org\/ornish-research\/\",\"url\":\"https:\/\/lifestylemedicine.org\/ornish-research\/\",\"name\":\"Ornish study shows lifestyle changes improved cognition in early Alzheimer\u2019s patients - 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